How does DNA recombination work? It occurs frequently in many different cell types, and it has important implications for genomic integrity, evolution, and human disease.

Dec 19, 2025 · Recombination occurs typically, though not exclusively, between regions of similar sequence by breaking and rejoining DNA segments, and is essential for generating genetic …

Recombination is a process by which pieces of DNA are broken and recombined to produce new combinations of alleles.

Beyond its role in meiosis, recombination is important to somatic cells in eukaryotes because it can be used to help repair broken DNA, even when the break involves both strands of the …

Meiosis also differs from mitosis in that it involves a process known as recombination, during which chromosomes exchange segments with one another. As a result, the gametes produced …

Jan 23, 2003 · The DNA double helix poses a major problem for the DNA recombination process, because the bases that need to pair to form a heteroduplex joint are buried in the interior of …

Specifically, meiosis creates new combinations of genetic material in each of the four daughter cells. These new combinations result from the exchange of DNA between paired chromosomes.

Mar 25, 2025 · This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-translational modifications throughout the cell cycle …

Oct 14, 2020 · The complex DNA transactions that take place during recombination are mediated by members of the RecA family of recombinase enzymes. During this process, RecA proteins …

Jul 3, 2008 · But before the explosion in recombinant DNA could begin, scientists would have to learn not only how to transfer DNA, but also how to isolate and modify individual genes.