Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...

Changing just one atom in a COVID-19 vaccine lipid redirects delivery from the liver to the spleen, improving tumor suppression in mice. The dominant ionizable lipids in approved vaccines attract ...

A new approach using lipid nanoparticles to deliver genetic material is showing promise in tackling two major challenges in ...

The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever and general malaise. Those symptoms, which typically resolve within days, are the natural ...

A team from the Max-Planck-Institut für Kohlenforschung, Hokkaido University, and Osaka University has discovered that subtle differences in molecular structure can have a major impact on the ...

When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear whether the mRNA ...

The modified lipid nanoparticle (CDL-LNP) contains several ingredients that work together to deliver mRNA effectively: the mRNA payload with genetic instructions, standard lipid molecules (ionizable ...

Researchers hold models of the aromatic rings they added to lipid nanoparticles, which could reduce the dosage mRNA vaccines need to achieve immunity. Penn Engineers have redesigned a key component of ...

A new material developed at Cornell University could significantly improve the delivery and effectiveness of mRNA vaccines by replacing a commonly used ingredient that may trigger unwanted immune ...

The mRNA vaccine CDMO market is rapidly expanding, driven by growing biotech startups, limited in-house manufacturing, and ...