Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...

Emerging and re-emerging viral threats continue to pose critical challenges to global health security. Despite substantial advances in our understanding of ...

Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically mediated. Although their exact etiologies remain uncertain, results from ...

The pathogenesis of polycystic ovary syndrome (PCOS) is not precisely known. There are several mechanisms that have been suggested to play a role in the pathogenesis of PCOS, including hormonal ...

Despite the long history of psoriasis and psoriatic arthritis (PsA), until recently, little had been known of their underlying genetics and pathogenesis. Without this knowledge, rational clinical ...

Familial Hypobetalipoproteinemia (FHBL), caused by variants in the apolipoprotein B (APOB) gene, is a rare autosomal ...

The etiopathogenesis of ankylosing spondylitis (AS) is not fully understood. However, there is strong evidence indicating that genetic factors play a pivotal role in disease susceptibility, and that ...