Jacksonville is only 1-6 in its last seven games in Indianapolis. Fortunately for coach Liam Coen’s team, the Jaguars are changing a lot of trends in a positive way. Jacksonville has a top-five defense over the past four weeks and a notable special-teams edge in this matchup. That’s why I’m picking the Jaguars to win and cover.

The Indianapolis Colts are going with 44-year-old quarterback Philip Rivers again. The San Francisco 49ers are battling for NFC playoff position.

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night Football. San Francisco is coming off a 37-24 win over the Tennessee Titans on Sunday,

Other highlights this weekend include two division matchups on Saturday (Eagles-Commanders and Bears-Packers), followed by a handful of must-see games on Sunday, including Bucs-Panthers, Jaguars-Broncos and Patriots-Ravens. Below, let's see if we can stay above .500 and carry some momentum into the second-to-last weekend of the regular season.

Week 17 of the 2025 NFL regular season has a lot on the line in its 16 games, from playoff implications to seeding scenarios to draft positions. The wild rather unpredictable league year should continue at the end of the calendar year.

We never lost faith in the Buffalo Bills last week, even when they fell behind by 21 points in New England, and correctly predicted the Philadelphia Eagles and Houston Texans would win by double digits. However, old man Philip Rivers cost us some money in his return to the field, and my patience with the Dallas Cowboys has clearly worn thin.