The immune system’s capacity to distinguish self from non-self is in large part mediated by immunoglobulins, with IgG playing a pivotal role in both protective and pathological responses.

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study ...

FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmenting FcRn can decrease autoimmune antibodies and enhance drug delivery.

A deep dive into the Fc–FcR axis as a therapeutic anchor in autoimmune disease, examining immune signaling and drug ...

A Japanese research team has uncovered how sugar chains (glycans) modifications dynamically regulate the structure and function of human immunoglobulin G (IgG) antibodies. By integrating nuclear ...