ascopubs.org

Identification of PDGFR-β activation as a potential bypass resistance pathway in a rhabdomyosarcoma (RMS) model of acquired resistance to IGF-1 receptor blockade.

IGF-1R inhibition effect on a yes/SFK bypass resistance pathway: Rational basis for cotargeting IGF-1R and yes/SFK kinase in rhabdomyosarcoma. Preclinical evidence of craniofacial adverse effect of ...
Medscape

Link between angiotensin II and IGF-1 raises hopes for treating skeletal-muscle wasting in HF

New Orleans, LA - Downregulation of insulin-growth-factor 1 (IGF-1) is the likely mechanism by which high angiotensin-II levels promote skeletal-muscle wasting in HF, a study in mice has found. [1] It ...
Medscape

Targeting Cancer Cells -- More Pathways, More Inhibitors, More Trials

The insulin and the IGF-1 pathway are closely intertwined. Both can bind the insulin receptor or the IGF receptor 1 (IGFR-1). IGF-2, on the other hand, can bind either IGFR-1 or the high-affinity IGFR ...
Kaleido Scope

In Type 1 diabetes, verapamil prevents decline of IGF-1 and promotes beta-cell IGF-1 signaling

Now UAB researchers, led by Guanlan Xu, Ph.D., and Shalev drilled down further into the mechanism underlying verapamil’s beneficial effect. In a paper published in Diabetes, they show that, in Type 1 ...
Science Daily

Insulin-like hormones critical for brain plasticity

Research has identified a mechanism through which insulin-like growth factors facilitate brain plasticity. The insulin super-family of hormones, including insulin, insulin-like growth factor 1 (IGF1), ...
News Medical

Study reveals mechanism through which insulin-like growth factors facilitate brain plasticity

Research from the Max Planck Florida Institute for Neuroscience has identified a mechanism through which insulin-like growth factors facilitate brain plasticity. The insulin superfamily of hormones, ...