Figure 1: Overview of the PAZ–siRNA-like duplex structure. The base edges of the 2-nt 3′-overhang residues are facing outwards towards solvent and have no contact with the protein. The absence of ...

The discovery of siRNA and its role in RNAi was a groundbreaking finding in the field of molecular biology. In 1998, Andrew Fire and Craig Mello published a seminal paper describing the phenomenon of ...

A new therapeutic strategy for treating Huntington’s disease patients that is based on small interfering RNA (siRNA) could have fewer side effects than earlier approaches (Chem. Biol., DOI: ...

Thanks to RNA interference it's easier than ever to perform genetic knockouts in cultured cells and live animals. The idea is simple enough: deliver a short interfering RNA (siRNA) for the desired ...

Using a technique known as “nucleic acid origami,” chemical engineers have built tiny particles made out of DNA and RNA that can deliver snippets of RNA directly to tumors, turning off genes expressed ...

Small interfering RNAs, or siRNAs, target complementary nucleotide sequences in order to destroy messenger RNA before it can be transcribed into a protein. Given that siRNAs can be used to ...

DNAsomes begin with short chains of synthetic DNA designed to be complementary over part of their length so they will join into microscopic Y-shapes. A lipid molecule is attached, and fluorescent dyes ...

A new therapeutic strategy for treating Huntington’s disease patients that is based on small interfering RNA (siRNA) could have fewer side effects than earlier approaches (Chem. Biol., DOI: ...