Researchers have defined a new genetic disease caused by a mutation in the IVNS1ABP gene. The condition marks a rare combination of premature physical aging and progressive neurological decline caused ...

Researchers at Cornell University have developed a powerful new genetic toolkit that allows scientists to study how genes ...

A new kind of microscope is giving scientists a way to watch life inside cells with a clarity that feels almost unfair. Instead of choosing between seeing big structures or tiny particles, researchers ...

Scientists have traced a devastating pattern of brain cell loss in a handful of families to a single, ultra-rare mutation that sabotages one of the brain’s key protective enzymes. The discovery not ...

Current techniques for imaging cells are limited to investigating a handful of different molecule types within a cell at one time. But being able to better measure molecular signals, and how cells ...

A new proof-of-concept method reliably engineered a hotspot mutation of SF3B1, a gene-splicing gene, into diverse cancer cell lines, outperforming other contemporary editing approaches. Oncogenesis ...

After an allogeneic stem cell transplant, a recipient’s body faces a daunting task: rebuilding the person’s blood-forming and immune systems from the ground up from a relatively small number of “seed” ...

Sickle cell diseases arises from hemoglobin protein mutations. The mutation causes red blood cells to form a sickle shape rather than a round one. One study suggests that this mutation could be ...

In mantle cell lymphoma (MCL), an aggressive form of B-cell non-Hodgkin lymphoma, TP53 mutations are known to affect patients’ prognosis—but questions remain. What does the heterogeneity of TP53 ...