Role of the RAAS in the Pathophysiology of Heart Failure ACE inhibitors have no effect on angiotensin II formed by alternate pathways. In contrast, ARBs would be expected to inhibit the biologic ...

Research that focused on blocking the renin-angiotensin system (RAS) led to the discovery of ACE inhibitors, which proved efficacious in the treatment of hypertension, various cardiovascular disorders ...

Atrial fibrillation, or AFib, is the most common heart rhythm disorder. With AFib, the beating of the upper chambers of your heart (the atria) becomes irregular, and blood has a harder time reaching ...

Although the two angiotensin II receptors are thought to be very similar, an X-ray study showed clear differences in the pockets where the receptors bind to drug-like compounds. This illustration ...

Vasodilatory shock is a life-threatening syndrome that requires immediate treatment; conventional vasopressors have a narrow therapeutic window and toxicities at high doses. New research findings are ...

Hypertension impairs blood vessels, neurons and white matter in the brain well before the condition causes a measurable rise in blood pressure, according to a new preclinical study from Weill Cornell ...