The San Francisco 49ers and Indianapolis Colts take the field for NFL Monday Night Football tonight in Week 16. MNF start time, TV schedule and how to watch.

Before discussing how the 49ers match up against the parade of flawed teams they may face along the way, I’m going to explain how, to the surprise of even the most optimistic Niners watchers, the team is surviving the Fred Warner and Nick Bosa injuries on defense — and why that unit has real upside to be better in January.

The San Francisco 49ers defeated the Indianapolis Colts 48-27 on Monday night, in their fifth straight win. Purdy threw for 295 yards, finishing with a career-high five touchdowns. Christian McCaffrey rushed 21 times for 117 yards, making six catches for 29 yards and two touchdowns.

The Bears and 49ers battle for top seeds in the NFC! Check our NFL odds series for the Bears-49ers prediction and pick.

Preview the Week 17 matchup between the San Francisco 49ers and Chicago Bears with predictions, odds, over/under, spread, betting lines and more.

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how to watch live and streaming.

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.